| Place of Origin: | China |
|---|---|
| Brand Name: | HNB |
| Certification: | ISO |
| Model Number: | Vildagliptin |
| Minimum Order Quantity: | 1KG |
| Price: | Negotiable |
| Packaging Details: | Aluminum foil bag |
| Delivery Time: | Usually3-5days |
| Payment Terms: | L/C, D/A, D/P, T/T, , MoneyGram，Alibaba Assurance Order |
| Supply Ability: | 5000kg/Month |
| CAS: | 274901-16-5 | Mf: | C17H25N3O2 |
|---|---|---|---|
| MW: | 303.4 | Specification: | 99% |
| Flash Point: | 153-155℃ | Appearance: | White Fine Powder |
| Usage: | Dietary Supplement Raw Materials | Sample: | Available |
API Pharmaceutical Medical Grade Vildagliptin 99% Powder CAS 274901-16-5
|
Product name |
Vildagliptin 99% |
|
Appearance |
White Powder |
|
CAS |
274901-16-5 |
|
MF |
C17H25N3O2 |
|
Purity |
99% |
|
Storage |
Keep in cool dry place. |
The Introductction of Vildagliptin 99%
The chemical formula of vildagliptin compound is (-) - (2S) - 1 - [[(3-hydroxytricyclic [3.3.1.1 [3,7]] silane 1-yl) amino] acetyl] pyrrolidine 2-carboxonitrile. The clinical drug is another oral dipeptidylpeptidase IV (DPP-IV) inhibitor after sitagliptin. It was approved by Novartis Pharmaceutical Co., Ltd. of Switzerland to be listed in the European Union in 2008 for the treatment of type 2 diabetes.
The Application & Function of Vildagliptin 99%
Vildagliptin is a selective, competitive and reversible DPP24 inhibitor. Glucose dependent insulinotropic polypeptide (GIP) and glucagon like polypeptide 1 (GLP-1) are important hormones to maintain glucose concentration in the body, both of which have the effect of incretin. In patients with type 2 diabetes, GIP's insulin stimulating effect is impaired. Only GLP-1 can play the role of insulin stimulating hormone secretion β Receptors on the cell membrane promote insulin secretion. GLP-1 can also inhibit the secretion of glucagon and gastric emptying, thus increasing satiety (inhibiting appetite). DPP24 binds to proteins and exists in many tissues, such as the brush like edges of the kidney, liver, and small intestine membranes, pancreatic ducts, lymphocytes, and endothelial cells. It can quickly inactivate GLP-1 by hydrolyzing its N-terminal second alanine. This product inhibits the activity of the enzyme by combining with DPP24 to form a DPP24 complex, thereby increasing the concentration of GLP-1 and promoting pancreatic islets β When cells produce insulin, they reduce the concentration of glucagon, thereby reducing blood sugar. And there is no significant impact on body weight
The COA of Vildagliptin 99%
| ITEMS OF ANALYSIS | SPECIFICATION | RESULT |
| Characteristics | White crystalline powder, odorless or practically odorless and practically tasteless | Complies |
| Identification | IR: The infrared absorption spectrum should be concordant with the reference spectrum | Complies |
| Solubility | Soluble in ethanol, chloroform, almost insoluble in water. | Complies |
| Water | ≤0.5% | 0.1% |
| ash content | ≤0.5% | 0.2% |
| Assay | 99% | 99.80% |
| Conclusion | Conform with the standard |
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